Replacement Therapy: General-interest Articles (Click links below to view articles)
USA Today: Gen-Mod Dental Treatment Gets Approval For Human Testing
Oragenics has won approval to conduct human trials of a dental treatment that uses genetically modified bacteria to prevent cavities for a lifetime... December 2004
The New York Times: Bacteria Enlisted for New Trials on Dental Health [ PDF - 131kb ]
Can genetically engineered bacteria prevent tooth decay? Oragenics is about to take the first step toward answering that question... November 2004.
Explore Magazine: Tackling Tooth Decay [ PDF - 2.7mb ]
Tooth decay, it's the most common childhood disease. Oragenics hopes to prevent a lifetime of tooth decay... Office of Research Pubications, University of Florida, August 2004.
Popular Science: Can Genetically Engineered Bacteria Cure Tooth Decay?
Kids get cavities. Dentists fill them. It's a fairly old arrangement, but it may soon come to an end... July 2004
THE WALLSTREET JOURNAL: Look, Ma, No Cavities! Oragenics is Offering an Oral Rinse for Life [ PDF - 92kb ]
A lifetime without cavities after a painless, five minute visit to the dentist probably sounds too good to be true. But Oragenics... October 29, 2003.
Fortune.com: Germs Make the Man [ PDF - 65kb ]
Your body is teeming with trillions of infectious microbes. That's a very good thing... February 2003.
ABCNEWS.com: A Bacteria That Could Keep Your Mouth Clean For Good
A new rinse that uses bacteria promises to prevent tooth decay in a single swish... February 2003.
Wired Magazine: Better Teeth Through Biochemistry
How mutant bacteria will win the fight against cavities... June 2002.
The Surgeon General's Report on Oral Health
Oral Health in America: A report of the Surgeon General May 2000.
Cavities, tooth loss still abound in U.S.
Find out why the U.S. Surgeon General has proclaimed Americans' poor oral health a "silent epidemic."
Oral Health America
Giving voice to a "Silent Epidemic" ... A report that investigates the disparities in the oral health of U.S. citizens.
Replacement Therapy: Scientific Articles (Not all articles are available to view. Click links below to view those that are available.)
Hillman, J.D., Mo, J., McDonell, E., Cvitkovitch, D., and Hillman, C.H. Modification of an effector strain for replacement therapy of dental caries to enable clinical safety trials. Journal of Applied Microbiology 2007:102:1209-1219.
View Abstract
Hillman, J.D. 2002. Genetically modified Streptococcus mutans for the prevention of dental caries. Antonie van Leeuwenhoek 82:361-366.
Hillman, J.D. 2001. Replacement therapy of dental caries. Oper. Dent. Suppl. 6:43-53.
Hillman, J.D., Brooks T.A., Michalek S.M., Harmon C.C., Snoep J.L., and Van Der Weijden C.C. "Construction and Characterization of an Effector Strain of Streptococcus mutans for Replacement Therapy of Dental Caries. Infection and Immunity, 2000;68(2):543-549. http://iai.asm.org
Hillman, J.D. 1999. Replacement therapy of Dental Caries. In: Dental Plaque Revisited: Oral Biofilms in Health and Disease. (H.N. Newman and M. Wilson, eds.) Bioline, Cardiff, UK., pp. 587-599.
Hillman J.D. "Principles of Microbial Ecology and Their Application to Xerostomia-Associated Opportunistic Infections of the Oral Cavity." Adv. Dent. Res. 1996;10(1):66-68. http://adr.iadrjournals.org
Hillman, J.D., Chen A. and Snoep J.L. "Genetic and Physiological Analysis of the Lethal Effect of L-(+)-Lactate Dehydrogenase Deficiency in Streptococcus mutans: Complementation by Alcohol Dehydrogenase from Zymomonas mobilis." Infection and Immunity.1996;64(10):4319-4323. http://iai.asm.org
Chen A., Hillman J.D., and Duncan M. "L-(+)-Lactate Dehydrogenase Deficiency Is Lethal in Streptococcus mutans." J. Bacteriol. 1994;176(5):1542-1545.
Hillman J.D., Chen A,. Duncan M., and Lee S.W. "Evidence that L-(+)-Lactate Dehydrogenase Deficiency Is Lethal in Streptococcus mutans." Infection and Immunity 1994;62(1):60-64. http://iai.asm.org/content/vol62/issue1/
Duncan M.J. and Hillman J.D. "DNA Sequence and In Vitro Mutagenesis of the Gene Encoding the Fructose-1,6-Diphosphate-Dependent L-(+)-Lactate Dehydrogenase of Streptococcus mutans." Infection and Immunity 1991;59(11):3930-3934. http://iai.asm.org
Hillman J.D., Duncan M.J. and Stashenko K.P. "Cloning and Expression of the Gene Encoding the Fructose-1,6-Diphosphate-Dependent L-(+)-Lactate Dehydrogenase of Streptococcus mutans." Infection and Immunity 1990;58(5):1290-1295. http://iai.asm.org
Hillman, J.D. and Socransky, S.S. 1989. The theory and application of bacterial interference to oral diseases. In: New Biotechnologies in Oral Research (H.M. Myers, ed.), S. Karger, Basel, pp. 1-17.
Hillman J.D., Andrews S.W., Painter S. and Stashenko P. "Adaptive Changes in a Strain of Streptococcus mutans during Colonization of the Human Oral Cavity." Microbial Ecology in Health and Disease 1989;2:231-239.
Stashenko K.P. and Hillman J.D. "Microflora of Plaque in Rats following Infection with an LDH-Deficient Mutant of Streptococcus rattus." Caries Res. 1989;23:375-377.
Taubman, M.A., Genco, R.J., and Hillman, J.D. "The Specific Pathogen-Free Human: A New Frontier in Oral Infectious Disease Research." Adv. Dent. Res. 1989;3(1):58-68. http://adr.iadrjournals.org
Hillman J.D., Dzuback A.L., and Andrews S.W. "Colonization of the Human Oral Cavity by a Streptococcus mutans Mutant Producing Increased Bacteriocin." Journal of Dental Research 1987;66(6):1092-1094.
Hillman J.D., Andrews S.W., Dzuback A.L. "Acetoin Production by Wild-Type Strains and a Lactate Dehydrogenase-Deficient Mutant of Streptococcus Mutans." Infection and Immunity 1987;55(6):1399-1402. http://iai.asm.org
Hillman, JD and Socransky, SS. "Replacement Therapy for the Prevention of Dental Disease." Adv. Dent. Res. 1987;1(1):119-125. http://adr.iadrjournals.org
Hillman, J.D., Andrews, S.W., and Dzuback, A.L. 1987. Acetoin production by wild-type strains and a lactate dehydrogenase-deficient mutant of Streptococcus mutans. Infect. Immun. 55:1399-1402.
Hillman, J.D., Dzuback, A.L., and Andrews, S.W. 1987. Colonization of the human oral cavity by a Streptococcus mutans mutant producing increased bacteriocin. J. Dent. Res. 66:1092-1094.
Hillman, J.D. 1982. Lactate dehydrogenase-deficient mutants of Streptococcus mutans. In: Genetic Engineering of Microorganisms for Chemicals (A. Hollander, ed.), Plenum Publishing Corp., New York, pp. 371-382.
Hillman J.D., Yaphe B.I. and Johnson K.P. "Colonization of the Human Oral Cavity by a Strain of Streptococcus mutans." Journal of Dental Research 1985;64(11):1272-1274.
Hillman, J.D. 1983. Analysis of lactate dehydrogenase mutants of Streptococcus mutans and their potential use in replacement therapy for caries prevention. Microbiology 1982:191-194.
Johnson K.P. and Hillman J.D. "Competitive Properties of Lactate Deyhdrogenase Mutants of the Oral Bacterium Streptococcus mutans in the Rat." Archs Oral Biol. 1982:27:513-516.
Hillman J.D. Analysis of Lactate Dehydrogenase Mutants of Streptococcus mutans and Their Potential Use in Replacement Therapy for Caries Prevention." Microbiology 1982.
Johnson C.P., Gross S.M., and Hillman J.D. "Carcinogenic Potential In Vitro in Man and In Vivo in the Rat of Lactate Dehydrogenase Mutants of Streptococcus mutans." Archs Oral Biol. 1980;25:707-713.
Hillman, J.D. 1980. Replacement therapy for the control of dental caries. The New Dentist 10:24-27.
Hillman, J.D. 1979. Mutant analysis of glyceraldehyde 3-phosphate dehydrogenase in Escherichia coli. Biochem. J. 179:99-107.
Hillman JD. Lactate Dehydrogenase Mutants of Streptococcus mutans: Isolation and Preliminary Characterization." Infection and Immunity 1978;21(1):206-212. http://iai.asm.org.
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